Healthy Body

You can’t outrun your microbes

Written by Healthy Living
Story: Dr. William B. Miller Jr.

Exercise doesn’t just affect muscles and joints.

Millions of Americans are serious about fitness because we have long been told of its benefits. It is well established that consistent exercise promotes long-term health by lowering blood pressure, improving glucose tolerance, and assisting in weight management. Most people who exercise report an additional positive: physical activity improves their mental outlook. Recent reports go even further: regular exercise may delay the onset of dementia for those who are prone.

However, those are not the only systems that are affected. Modern research has documented many substantial changes that occur with exercise in our gut microbiome, which is being reshaped due to metabolic changes that incur from regular moderate exercise. Exercise is associated with an increase in gut microbial diversity, which is associated with an improved metabolic profile and a strengthened immune system. This shift is believed to result from an increase in a particular bacterial strain, bifidobacteria, that is essential for optimum health and whose levels tend to decline with age. Exercise provides a valuable boost.

Although most people exercise in the moderate range, there are increasing numbers of recreational and elite performance athletes who engage in high levels of physical exercise to enhance performance. Extreme exercise is associated with challenges, of course, including a 10 to 20 percent increase in heart size and an increased potential for cardiac arrhythmias. More recent evidence suggests there also is a general immune deficiency associated with prolonged exertion. In fact, it is common for elite athletes at the peak of training fitness during preparation for major sporting events to be prone to respiratory illnesses and a range of gastrointestinal symptoms. It has been documented that among ultra-marathoners, there is an increased risk of upper respiratory tract infection during periods of heavy training and the one- to two-week period after marathon-type race events.

Previously, it had been supposed that the depressed immune function coincident with strenuous exertion and heavy training was a byproduct of dietary deficiencies in protein, carbohydrates, or specific micronutrients. However, there is new evidence for a surprisingly different common denominator for this set of problems that is centered within the gut microbiome. Extreme exercise is associated with gut-related immune deficiency from increased permeability of the intestinal cells that line our gut. This disruption leads to the common symptoms of nausea, bloating, cramping, pain, diarrhea, and even bleeding. Under the chronic stress of exercise-induced muscle fatigue and dehydration, the intestinal cells cannot sufficiently counteract and detoxify the free radicals that are being produced by extreme exertion. In these circumstances, some of the less desirable products of ongoing gut microbial metabolism cross the gut lining barrier—a condition known as endotoxemia.

Extreme endurance training has is associated with a rise in inflammatory markers in the body and a breakdown of gut integrity. These are known pathways toward chronic disease.

Fortunately, there is a way to counteract these negative effects. Several studies indicate a benefit from prebiotic and probiotic supplements for serious recreational and elite athletes. For example, prebiotics, such as oligo-fructose enriched insulin, increase the number of the beneficial bifidobacteria and lactobacillus in the colon. These bacteria protect against pathogens and antioxidants and stimulate the immune system. A specific byproduct of bifidobacteria metabolism, butyrate, is an essential metabolite in our colon that helps maintain the energy supply of the body cells that line the colon and protects gut integrity. It is now known that increasing the proper microbes in your gut enhances these protective effects. The good news for recreational and endurance athletes is there are convenient means to prevent the most common non-muscular complications of strenuous exercise. Certainly, the best advice for your optimum health is to exercise in moderation and support those efforts with a balanced and nutritious diet. But, if you insist on pushing toward even higher levels of athletic performance, part of your exercise regimen should include a daily supplement to boost your gut microbes, which are among your most important athletic partners.

About the writer

 Dr. Bill Miller has been a physician in academic and private practice for more than 30 years. He is the author of “The Microcosm Within: Evolution and Extinction in the Hologenome.” He serves as a scientific advisor to Prebiotin. For more information, visit

About the author

Healthy Living

Healthy Living is unique in a sea of health magazines that only present information on nutrition and exercise. Published by Akers Media Group, Healthy Living goes much farther by focusing on the four pillars of a true wellness — physical, mental, spiritual and financial health.

Healthy Living promotes a healthy, well-balanced lifestyle with easy-to-read features, try-it-at-home exercise programs, and expert advice from financial planners, mental health professionals, and a variety of other leaders in their respective fields.

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